If you have troubles since the update to WordPress 4.5 please read this post before opening a new thread.
The best thing I can suggest is to go through the wordpress permalinks issues/troubleshooting here: http://codex.wordpress.org/Using_Permalinks#Fixing_Permalink_Problems
Permalinks can be very tricky depending on your hosting setup and how much control you have over your host and settings. You may also want to contact your hosting provider and see if they can help since permalinks and WordPress or *very* popular and most hosts are familiar with it.
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